Saturday, June 30, 2012

Happy Canada day weekend!

Working till 2. Going to see some stand up comdey tonight. How far back from the stage do you reckon you have to be to be guarenteed not to get bullied by the comic?

Going to Derby on Sunday to get drunk and watch Italy win the European Championship.

Source: http://drownedinsound.com/community/boards/social/4357021

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5 personal financial mistakes to avoid | Personal Finance Blog ...

There may be various ways to manage personal finance. But some may manage it better than the rest by following certain conditions and maintaining some golden rules. It thus depends on your expertise to manage it in a better way. There may be various loopholes and you need to take care that you do not make any mistakes.

If you want to resolve your debts and have a steady financial state it is required that you learn to manage your finances well without any defaults. Given below are some of the mistakes that commonly lead to financial mismanagement. You need to consider them carefully and avoid any personal financial mistakes of any sort:

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  1. Absence of a well framed budget plan: If you have not framed a proper budget plan it will surely affect your personal financial adversely. It will be a serious mistake on your part as you will not have an idea of your total income and expenditure for various spheres. You will also not have the idea of where your income is actually being spent. If you have a well framed budget plan you can divide your personal finance according to the need and utilize them in the best possible way without acquiring any new loans or debts.
  2. Disparity between income and expenditure: If the amount you spent is more than the amount you earn it can lead to a deficit in your personal finances. This problem will arise when you do not have control over your expense. Impulsive shopping or endless expenditure can lead to imbalance between your income and expense and can disrupt your personal financial condition.
  3. Defaults on payments: If you have any loans or debts that you need to resolve late payments or default on payments on those can get you into problems. If you default on payments you end up paying more after some time as interests are added to the principal payments. In order to avoid this problem set reminders or automatic payment options so you do not incur additional debts.
  4. Savings plan held unimportant: If you think having a savings plan is not important then you will be doing another serious mistake. It is in fact very important that you have a savings plan from the very beginning itself. Try and put aside a part of your income as saving every month. This will serve as a back-up and help you to pay your debts later.
  5. Cheaper deals missed out: If you are not well informed about the deals available in the market there are chances that you will miss out on the cheap deals and discounts. These deals are offered during a particular season and are very useful in saving you some bucks. If you want to get the best possible deal in the market try and make some research on the product before you buy it. Do try out the online options too. You may get a better deal out there.

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It is thus not much difficult to manage your personal finances properly if you are a little careful in avoiding the above mistakes.

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Source: http://www.personal-finance-blog.com/2012/06/30/5-personal-financial-mistakes-to-avoid/

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Healthy Food: 50 Of The Best In The World

  • Almonds

    Almonds are a rich source of fiber, protein, heart-healthy fat, antioxidants and vitamins and minerals, making them a one-stop food. "[They make] a great snack but watch your portion size as almonds are high in calories," warn Johnson and Bickford. "Stick to no more than one ounce." That's 23 whole, shelled nuts. While the monounsaturated fat works to lower LDL cholesterol, their significant dose of vitamin E provides antioxidant power. What's more, a quarter-cup of almonds has about 100 milligrams of magnesium (about 25 percent of a daily allowance), which promotes vascular and heart health, and 257 milligrams of potassium, which helps prevent high blood pressure. These benefits also have a track record in real-world scenarios: in five longitudinal cohort studies, <a href="http://www.ncbi.nlm.nih.gov/pubmed/11122711" target="_hplink">including the Iowa Women Health Study and the Nurses' Study</a>, researchers found that replacing some portion of carbohydrate with nuts like almonds led to a heart disease risk reduction of 30 percent. And in a study in the journal <em>Metabolism</em>, <a href="http://www.nutritionandmetabolism.com/content/8/1/6/" target="_hplink">researchers found that eating almonds</a> along with a high glycemic index food (such as white bread, potatoes or sweets) at breakfast significantly lowered the overall glycemic index of the meal by helping to modulate the postprandial blood sugar rise.

  • Apples

    Apples are an "excellent source of pectin, a soluble fiber that can lower blood cholesterol," says Wixom. The fruit is also high in fiber and its peel contains something called ursolic acid, which has been shown in recent studies to lower the incidence of obesity. "Apples also contain quercetin, which has anti-inflammatory properties and can help in preventing respiratory problems," Heather Bauer tells The Huffington Post. "Research shows that pregnant women who incorporated apples into their daily diet were less likely to give birth to a child with asthma."

  • Artichoke Hearts

    These small greenish-yellow veggies are jam-packed with fiber -- 12 grams per cup, in fact. And a diet sufficient in fiber helps to promote healthy weight and cholesterol levels -- and digestive health. But what's more, a <a href="http://www.ajcn.org/content/84/1/95.abstract">2006 study</a> in the <em>American Journal of Clinical Nutrition</em> found that artichoke hearts had the highest antioxidant density of any vegetable, beating out such well-known antioxidant powerhouses as blueberries, dark chocolate and grapes.

  • Avocado

    Packed with heart-healthy monounsaturated and polyunsaturated fat that help people feel satiated, avocados are also rich sources of vitamin C, E, potassium, and lutein. And, points out Politi, when paired with salsa or salad, the monounsaturated fat helps us better absorb carotenoids, lycopene and beta-carotene -- an important class of antioxidants found in many vegetables that help to protect against everything from cancer to eye health problems to heart disease. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15629237">Early research</a> has also found that the fruit could play a role in inhibiting the growth of prostate cancer cells.

  • Beets

    "The dark red color indicates the powerful phytonutrient package of beets," Diekman tells The Huffington Post. Indeed beets are rich in betalains, such as betanin and vulgaxanthin, that give them their pigment and also have anti-inflammation and antioxidant properties. Beyond that, beets contain significant amounts of folate, vitamin C, B6, iron, phosphorous, calcium, magnesium, zinc, niacin, riboflavin and thiamine.

  • Beans

    Thanks to a certain gross-out childhood rhyme, everyone knows that beans are good for your heart thanks to a high fiber content. Their fiberous quality also makes them protective against certain cancers and a top-rated food for diabetics, <a href="http://www.diabetes.org/food-and-fitness/food/what-can-i-eat/diabetes-superfoods.html" target="_hplink">per the American Diabetes Association</a>. And when combined with a grain, they comprise a high-quality vegetarian source of complete protein. Beans are an excellent dietary source of folate and also have high levels of iron, potassium and magnesium, according to Wixom, which help with bone health and blood pressure levels.

  • Bell Peppers

    The peppers are "loaded with vitamin C," says Joy Bauer. But unlike many other sources of the nutrient, bell peppers are relatively low in sugar, while also providing fiber and several antioxidants from the carotenoid class (alpha-carotene, beta-carotene, lycopene, lutein, cryptoxanthin and zeaxanthin). Carotenoids improve eye health, and are associated with a <a href="http://pac.iupac.org/publications/pac/pdf/2002/pdf/7408x1451.pdf">reduction in cancer risk </a>and a <a href="http://www.ajcn.org/content/83/6/1265.full"> lower risk of cardiovascular-related death</a>. And at least one study found that they can <a href="http://healthland.time.com/2011/01/12/study-can-a-veggie-rich-diet-make-you-more-beautiful/"> make you appear more beautiful</a>.

  • Blackberries And Raspberries

    Berries are low in calories and are excellent sources of fiber, vitamin C, antioxidants and phytochemicals, and, according to Wixom, some research suggests they help with such divergent health challenges as age-related mental decline, heart disease, some cancers and urinary tract infections. On the mental acuity front, the berries are full of anthocyanins for boosting memory, according to Joy Bauer, but that's not their only age-related benefit. "These foods are high in antioxidants, protect the body from the harmful effects of by-products known as free radicals, made normally when the body changes oxygen and food into energy," according to experts at the Penn Institute on Aging at the University of Pennsylvania.

  • Black Tea

    Along with green and white teas, black tea is full of antioxidant flavonoids. "Studies suggest [they] may have strong anti-inflammatory and immune boosting properties, be protective against certain cancers, cardiovascular disease and diabetes," says Heller. "Just don't load your tea up with sugar and cream!" On the other hand, adding a squeeze of lemon could help your body absorb antioxidants as well. But don't think that the compounds from tea are just the same as those found in other antioxidant-rich items like fruits and vegetables -- flavonoids are distinctly different, according to tea researcher John Weisburger, who <a href="http://www.webmd.com/food-recipes/features/antioxidants-in-green-and-black-tea">told WebMD</a>: ""In my lab, we found that green and black tea had identical amounts of polyphenols. We found that both types of tea blocked DNA damage associated with tobacco and other toxic chemicals. In animal studies, tea-drinking rats have less cancer."

  • Blueberries

    While <em>all</em> berries provide healthful antioxidants, vitamins, fiber and phytochemicals, studies show that blueberries have a particular and unique health benefit. "Among the fruits with the highest level of antioxidants, blueberries have been linked to lowering cholesterol, reducing diabetes risk, slowing the aging process, improving motor skills and supporting urinary and vision health," says Fitzgerald. "The compound, anthocynanin, gives blueberries their color and may be the main component of its antioxidant and anti-inflammatory properties."

  • Broccoli

    "Broccoli is high in fiber, low in calories, rich in the antioxidants vitamin C and beta carotene," says Young. But that's not all: according to Politi, the cruciferous vegetable is also rich in vitamins K, E, B and the minerals, calcium, iron, selenium and potassium. And that means broccoli is something of a wonder-food, promoting eye health and preventing macular degeneration with the carotenoids lutein and zeaxanthin; protecting against cancer, heart disease, stroke; building strong bones, thanks to calcium; and fortifying the immune system. But it's their richness in sulforaphane (what also gives them a slightly unpleasant smell) that research shows may help fight breast cancer. In fact, in <a href="http://www.nlm.nih.gov/medlineplus/news/fullstory_123681.html">one recent Chinese study</a>, women who consumed the most cruciferous vegetables were 62 percent less likely to die of breast cancer and, if they had a history of breast cancer, were 35 percent less likely to experience a recurrence.

  • Brown Rice

    Fiber-packed and nutrient dense brown rice helps fill you up while being relatively low in calories," say Johnson and Bickftoord. What's more, <a href="http://www.hsph.harvard.edu/news/press-releases/2010-releases/white-rice-brown-rice-whole-grains-diabetes.html">a 2010 Harvard study</a> found that eating two or more servings of brown rice helped protect against Type 2 diabetes, compared to five servings of white rice, which actually <em>increased</em> the risk. And <a href="http://www.sciencedaily.com/releases/2006/03/060302180051.htm">a 2006 rat study</a> found that brown rice might specifically help to lower blood pressure.

  • Brussels Sprouts

    "Consuming cruciferous vegetables like Brussels sprouts may play a role in protecting against heart disease perhaps by reducing inflammation," Zied tells The Huffington Post. They contain important nutrients like omega 6 fatty acids (in the form of ALA), vitamin A, B vitamins (thiamine, niacin, and folate), and vitamin E, according to Zied. And that's not all: <a href="http://www.hopkinsmedicine.org/avon_foundation_breast_center/treatments_services/nutrition.html">according to advice</a> for breast cancer patients from Johns Hopkins University School of Medicine, the antioxidant, antiestrogen and chemopreventive properties of the Brussels sprouts may make them useful in preventing recurrence of cancer.

  • Cherries

    These tartly sweet fruits are packed with vitamins A and C, iron and calcium, and are a low-calorie food to boot. Zied explains that they also are a good source of fiber, and have virtually no sodium or fat. Cherries are "packed with antioxidants, and emerging studies suggest that eating cherries or drinking cherry juice may promote heart health, play a role in pain management, support recovery from exercise, and even help you fall asleep faster," Zied tells HuffPost. Experts at the Penn Institute on Aging at the University of Pennsylvania also note that cherries' antioxidants help to "protect the body from the harmful effects of by-products known as free radicals, made normally when the body changes oxygen and food into energy." <em>Flickr photo by <a href="http://www.flickr.com/people/dhwright/" target="_hplink">D H Wright</a></em>

  • Chia Seeds

    Chia seeds are actually from the Salvia hispanica plant, and have been a part of the <a href="http://www.drweil.com/drw/u/QAA365093/Chia-for-Health.html" target="_hplink">diets of the Aztecs and Mayans</a>. The little seeds are super-rich in antioxidants and omega-3 fatty acids, which research has shown to be important in lowering inflammation in the body and <a href="http://www.umm.edu/altmed/articles/omega-3-000316.htm/" target="_hplink">reducing the risk of heart disease</a> and cancer. Heather Bauer says that she loves putting chia seeds as a topping for yogurt in order to boost calcium and fiber intake. "A one tablespoon sprinkle contains 6 grams of fiber and is full of beneficial omega-3 fatty acids to reduce inflammation," Bauer tells HuffPost. "They're also abundant in antioxidants and contain more calcium than milk per serving." And Joy Bauer says that chia seeds actually have more calcium and fiber than the notoriously healthy flaxseed. <em>Flickr photo by <a href="http://www.flickr.com/people/notahipster/" target="_hplink">little blue hen</a></em>

  • Coffee

    Ah, coffee. The perks of this remarkable brew have been more and more researched lately, with <a href="Ah, coffee. The perks of this remarkable brew have been more and more researched lately, with potential health benefits including the ability to protect against heart failure, lower depression risk, lower risk of some cancers, protect against diabetes and possibly even help you live longer. Joy Bauer also points out that coffee is high in antioxidants, which is great for brain health. " target="_hplink">potential health benefits</a> including the ability to protect against <a href="http://www.huffingtonpost.com/2012/06/26/coffee-heart-failure_n_1624804.html?utm_hp_ref=health-news&ir=Health News" target="_hplink">heart failure</a>, lower <a href="http://www.huffingtonpost.com/2011/09/27/coffee-cuts-depression-women_n_982122.html " target="_hplink">depression risk</a>, lower risk of <a href="http://www.huffingtonpost.com/2011/10/24/coffee-most-common-cancer_n_1025089.html" target="_hplink">some cancers</a>, protect <a href="http://www.huffingtonpost.com/2011/10/31/coffee-health-benefits_n_1064577.html#s440654&title=Coffee_Could_Protect" target="_hplink">against diabetes</a> and possibly even help you <a href="http://www.huffingtonpost.com/2012/05/17/coffee-longer-life-new-research-finds_n_1524228.html" target="_hplink">live longer</a>. Joy Bauer also points out that coffee is high in antioxidants, which is great for brain health.

  • Cranberries

    This little red fruit is actually a powerful <a href="http://www.umm.edu/altmed/articles/cranberry-000235.htm" target="_hplink">urinary tract infection preventer</a>, as it's able to stop bacteria from clinging to the urinary tract walls, according to the University of Maryland Medical Center. However, the National Center for Complementary and Alternative Medicine notes that there is not yet enough evidence to say that cranberries can actually <em>treat</em> UTIs. Some studies have also shown that cranberries have <a href="http://nccam.nih.gov/health/cranberry" target="_hplink">lots of antioxidants</a> and may even be able to lower the amount of dental plaque we have in our mouths (which is a risk factor for gum disease, according to the National Center for Complementary and Alternative Medicine. However, it's important to keep in mind that <em>juices</em> made of cranberries often contain <a href="http://www.umm.edu/altmed/articles/cranberry-000235.htm" target="_hplink">high amounts of sugar</a>, so look out for types that are sugar free, the University of Maryland Medical Center advises. <em>Flickr photo by <a href="http://www.flickr.com/people/29682030@N00/" target="_hplink">Bruce Foster</a></em>

  • Dark Chocolate

    How sweet it is that this sweet can actually be good for us? Ding notes that the flavonoids in cocoa are able to <a href="http://www.huffingtonpost.com/2012/06/01/dark-chocolate-heart_n_1561014.html" target="_hplink">protect the heart</a> from disease by lowering blood pressure, raising <a href="http://www.huffingtonpost.com/2012/04/30/dark-chocolate-health-cholesterol-blood-sugar_n_1452799.html" target="_hplink">levels of "good" cholesterol</a> and lowering levels of "bad" cholesterol, helping with blood flow and even improving insulin sensitivity. However, Ding also says that chocolate is high in calories and fat, and so supplements of cocoa flavonoids may be a better option for getting the full benefits of chocolate, instead of eating several bars a day. For more health benefits of chocolate, <a href="http://www.huffingtonpost.com/2012/03/28/chocolate-health-benefits_n_1383372.html" target="_hplink">click here</a>. <em>Flickr photo by <a href="http://www.flickr.com/people/cursedthing/" target="_hplink">cursedthing</a></em>

  • Edamame

    This green soy bean is packed to the gills with important nutrients like folate, protein, magnesium, potassium and fiber, Heller says, estimating that "one half a cup has about 8 grams of protein." And studies have shown that soy-containing foods -- such as tofu and edamame -- may even be able to protect the body from diseases like diabetes, cancer and heart disease, Heller says. <em>Flickr photo by <a href="http://www.flickr.com/people/joyosity/" target="_hplink">joyosity</a></em>

  • Eggs

    "Eggs provide perfect protein in a nutrient-rich, low-calorie, low-fat package," Katz says. That's because they are <a href="http://www.health.harvard.edu/press_releases/egg-nutrition" target="_hplink">full of choline</a> -- which is good for memory -- as well as the vision protectors lutein and zeaxanthin, Harvard Medical School says. Eggs <em>do</em> contain cholesterol -- about 212 milligrams per large egg, according to <a href="http://www.health.harvard.edu/press_releases/egg-nutrition" target="_hplink">Harvard Medical School</a> -- but the Mayo Clinic points out that having <a href="http://www.mayoclinic.com/health/cholesterol/HQ00608/" target="_hplink">four egg yolks a week</a> doesn't seem to have an effect in increasing heart disease risk or most people. Eggs' "dietary cholesterol is of limited, if any, importance," Katz says. <em>Flickr photo by <a href="http://www.flickr.com/people/donutgirl/" target="_hplink">telepathicparanoia</a></em>

  • Flax Seed

    Flax seeds are high in omega-3 fatty acids, fiber and <a href="http://lpi.oregonstate.edu/infocenter/phytochemicals/lignans/" target="_hplink">lignans</a> (a phytonutrient linked with lower risks of heart disease and possibly some cancers), Katz says. HuffPost blogger Kathy Freston, a health activist and author, notes in a past blog post that the abundant amount of fiber in flax seed <a href="http://www.huffingtonpost.com/kathy-freston/lean-challenge_b_1432764.html" target="_hplink">makes you feel full faster</a> <em>and</em> keeps blood sugar stable. Freston notes in her blog post that <a href="http://www.huffingtonpost.com/kathy-freston/lean-challenge_b_1432764.html" target="_hplink">flaxseeds can be purchased ground</a> or whole (and you can grind them on your own in a coffee grinder) and then added to foods like oatmeal, salads or smoothies.

  • Ginger

    A "superstar of Traditional Chinese Medicine," ginger root can be consumed as a tea (from boiled root) or eaten sliced as part of a dish, according to Fitzgerald. "Ginger has demonstrated anti-inflammatory properties, can help with nausea and digestive challenges [and] possesses anti-viral properties," she says. The National Institutes of Health also notes that ginger -- fresh dried, and/or juiced-- can also be <a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/961.html" target="_hplink">used to treat migraines</a>, toothache, rheumatism, cough, upper respiratory tract infections, stomach pain and burns. <em>Flickr photo by <a href="http://www.flickr.com/people/dinnerseries/" target="_hplink">Dinner Series</a></em>

  • Greek Yogurt

    Even though Greek yogurt is trendy right now, it <em>does</em> live up to its nutritional name, says Diekman. Greek yogurt provides "a good dose of protein and is an important source of calcium, potassium and phosphorous." In fact, the amount of protein obtained from Greek yogurt is actually twice that of traditional yogurt, Joy Bauer notes. However, U.S. News reports that Greek yogurt <em>does</em> have a significant fat content, with 16 grams of saturated fat in a six-ounce full-fat Greek yogurt from Fage. Therefore, to decrease fat intake, it may be wise to <a href="http://health.usnews.com/health-news/diet-fitness/diet/articles/2011/09/30/greek-yogurt-vs-regular-yogurt-which-is-more-healthful" target="_hplink">choose low-fat or nonfat options</a>.

  • Green Tea

    Green tea, made of unfermented tea leaves, has the highest amount of polyphenols -- a kind of plant-derived antioxidant -- compared to other teas, Politi says. These antioxidants keep the heart and brain healthy, and even protect against cancer. Recently, a study in <a href="http://www.ajcn.org/content/95/3/732" target="_hplink">the <em>American Journal of Clinical Nutrition</em></a> showed that elderly people who made <a href="http://www.huffingtonpost.com/2012/02/08/green-tea-functioning-old-age_n_1258028.html" target="_hplink">green tea consumption</a> a part of regular life were also more likely to retain their independence and not have "functional disability." Studies have also shown that drinking <a href="http://www.umm.edu/altmed/articles/green-tea-000255.htm" target="_hplink">three cups of green tea a day</a> can decrease heart attack rate by 11 percent, and that it can also raise levels of "good" HDL cholesterol, the University of Maryland Medical Center reported. Other research has linked drinking green tea with lower levels of bladder, breast and colorectal cancer. <em>Flickr photo by <a href="http://www.flickr.com/people/mckaysavage/" target="_hplink">mckaysavage</a></em>

  • Kale

    This dark leafy green is <a href="http://www.mayoclinic.com/health/vegetarian-diet/hq01596/nsectiongroup=2" target="_hplink">loaded with calcium</a>, which is good for bone and teeth health. "Kale contains most of the important vitamins and minerals needed to help the body grow and work the way it should," say experts at the Penn Institute On Aging. "Vitamins help resist infections, keep nerves healthy, and help the body get energy from food or blood to clot properly."

  • Kefir

    Kefir is a probiotic drink made of milk, typically from cows or goats, that has been fermented with kefir grains. Forberg notes that the beverage is a "scrumptious source of calcium, protein and probiotics to aid our digestion," and is also a welcome substitute in smoothies for milk or yogurt. Studies have shown that probiotics can improve our health by amping up the immune system and fighting infections. For the complete guide to probiotics, <a href="http://www.huffingtonpost.com/2012/05/15/probiotic-remedies_n_1507166.html" target="_hplink">click here</a>.

  • Lentils

    Think you need meat to fulfill your protein requirements? Think again. <a href="http://www.huffingtonpost.com/2012/05/24/vegetarian-protein-sources_n_1539928.html#slide=1013134" target="_hplink">As The Huffington Post reported</a> earlier this month, just a cup of lentils is loaded with 18 grams of protein (about the same amount as three ounces of steak). That means lentils have enough high quality protein to substitute for meat in your diet, Katz says. And when that protein is combined with the fiber in lentils, it becomes a "dynamic duo" for satiety, Zeid explains. "Not only do they fill you up and give you the unique combination of complex carbohydrates -- essential fuel that your body and brain rely on -- and protein," she says, "but they also provide valuable vitamins and minerals including folate, manganese, thiamin, potassium and copper." They may also lower LDL (or bad cholesterol), raise HDL (good cholesterol) and lower heart disease, according to Zeid.

  • Oatmeal

    This breakfast superstar is a great source of soluble fiber, Diekman says -- and that means it keeps you full way past the morning hours. Oatmeal is also a proven <a href="http://www.sciencedaily.com/releases/2008/01/080108102225.htm" target="_hplink">cholesterol reducer</a>. Oats are additionally a solid source of vitamins B1, B2 and E, and minerals zinc and iron, Politi says. Added bonus? Diekman points out that oatmeal tastes great with berries and walnuts as toppings, both of which are on the list in their own right.

  • Olive Oil

    This heart-healthy oil contains monounsaturated fatty acids (also known as MUFAs), which, according to experts at the Penn Institute on Aging, provide energy and keep you feeling fuller longer. MUFAs are among the so-called healthy class of fats that might lower risk of heart disease. "For instance, MUFAs may lower your total cholesterol and low-density lipoprotein cholesterol levels," <a href="http://www.mayoclinic.com/health/food-and-nutrition/AN01037" target="_hplink">Donald Hensrud, M.D. told the Mayo Clinic</a>, pointing out that these fats might also help with clotting. "And some research shows that MUFAs may also benefit insulin levels and blood sugar control, which can be especially helpful if you have Type 2 diabetes." Just remember that olive oil isn't low-cal (one tablespoon has <a href="http://nutritiondata.self.com/facts/fats-and-oils/509/2" target="_hplink">119 calories</a>) so stick with a drizzle to max out your benefits without overdoing it on your calorie count.

  • Oranges

    Oranges (and their other citrus cousins, like grapefruit) are a solid source of fiber, folate, antioxidants, photochemicals and, of course, <a href="http://www.huffingtonpost.com/2012/04/27/vitamin-c-foods_n_1457397.html" target="_hplink">vitamin C</a>, Wixom says. And, in turn, vitamin C is important for immune function, wound healing and as an aid in iron absorption, she explains.

  • Pistachios

    "Not only do they taste great, but they fill you up because of their protein and fiber content," Zied says of these little green nuts. She also points out that they make a good source of nutrients such as vitamin B6, thiamin, copper and phosphorous, as well as some potassium. Pistachios also rank high for antioxidant content, Zied says, and several studies have linked them to heart health (including new research recently <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=pistachios hypertension" target="_hplink">published in the journal <em>Hypertension</em></a>, suggesting that the nut might reduce blood pressure when under stress).

  • Pomegranate

    These tasty little seeds pack a powerful punch of antioxidants to promote heart health, Forberg says. Pomegranate is also a good source of dietary fiber, folate, vitamin C and vitamin K, <a href="http://nutritiondata.self.com/facts/fruits-and-fruit-juices/2038/2" target="_hplink">according to Self Nutrition Data</a>. Forberg suggests adding them to cereal, using them to top off a salad, squeezing the juice into a cocktail or just snacking on them plain.

  • Potatoes

    Potatoes get a bad rap -- and for good reason when they're fried up or slathered in butter. But in their pure form, spuds can actually find a place in a healthy diet. According to Zied, potatoes are, "rich in complex carbohydrates, relatively low in calories, and virtually free of fat, cholesterol and sodium." They're also rich in vitamin C, B and potassium -- and the skins contain dietary fiber that helps to fill you up, she explains. One small, preliminary 2011 study also found that purple potatoes might help to lower blood pressure, maybe even as much as oatmeal, <a href="http://yourlife.usatoday.com/fitness-food/diet-nutrition/story/2011-09-01/Potatoes-especially-purple-may-help-lower-blood-pressure/50218024/1" target="_hplink"><em>USA Today</em> reported</a> when the findings were released.

  • Quinoa

    According to Forberg, quinoa is easy to prepare and versatile -- it works in everything from breakfast to dinner. And it's healthy, to boot. Forberg calls quinoa a "powerhouse of nutrition," as well as a "complete protein." <a href="http://nutritiondata.self.com/facts/cereal-grains-and-pasta/10352/2" target="_hplink">According to Self Nutrition Data</a>, it's also a solid source of magnesium, phosphorus and especially manganese.

  • Red Wine

    Cheers to this one: according to Young, red wine (and red grapes) contain <a href="http://www.mayoclinic.com/health/red-wine/HB00089/" target="_hplink">resveratrol</a>, a compound that acts as an antioxidant and might even reduce inflammation and blood clot formation. Not bad for 100 calories in a four ounce serving (just remember that <a href="http://www.cdc.gov/alcohol/faqs.htm/#moderateDrinking" target="_hplink">experts typically define</a> moderate drinking as one glass a day for women and two for men -- anything beyond that can cause health problems). On top of these red wine-specific perks, alcohol in general has been found to boost our good cholesterol, or HDL, Politi points out.

  • Salmon

    Salmon was perhaps one of the most popular items among our experts -- almost all of them recommended including it. As Katz puts it, this fish superstar is a "delicious source of great protein and concentrated omega 3," he says. "What more needs to be said?" Forberg explains that those omega 3s make you healthy from the inside out, promoting heart health, brain health, soft skin and shiny hair. For more on how to pick the healthiest salmon (wild vs. farmed, frozen vs. fresh, etc.), check out <a href="http://www.huffingtonpost.com/eatingwell/buying-salmon_b_1387686.html" target="_hplink">this piece from our partner</a>, <em>EatingWell</em>.

  • Sardines

    Nutritionist and author Dr. Jonny Bowden, author of "The 150 Healthiest Foods On Earth," <a href="http://well.blogs.nytimes.com/2008/06/30/the-11-best-foods-you-arent-eating/" target="_hplink">once told the <em>New York Times</em> that sardines</a> are basically "health food in a can." These little fish (their name, <a href="http://www.drweil.com/drw/u/QAA400957/Herring-or-Sardines.html" target="_hplink">in fact, means "small fish"</a>) are among the best sources of Omega-3 fats, <a href="http://www.eatingwell.com/recipes_menus/recipe_slideshows/healthy_sardine_recipes" target="_hplink">according to <em>Eating Well</em></a>, with a full 1,950 mg per three ounce serving. And Omega-3s, in turn, help with <a href="http://www.hsph.harvard.edu/nutritionsource/questions/omega-3/index.html" target="_hplink">blood clotting and support healthy brain function</a>, among other health benefits. Sardines also <a href="http://nutritiondata.self.com/facts/finfish-and-shellfish-products/4114/2" target="_hplink">pack a healthy punch</a> of niacin, calcium, protein, vitamin D, vitamin B12, phosphorus and selenium. Added bonus? <a href="http://www.drweil.com/drw/u/QAA400957/Herring-or-Sardines.html" target="_hplink">HuffPost blogger Dr. Andrew Weil points out on his website</a> that because sardines are closer to the bottom of the food chain, they don't have the same contaminants found in larger fish.

  • Seaweed

    "This is my favorite low-calorie food for when I'm craving something salty and crunchy," Heather Bauer says. She explains that it's packed with vitamin C, vitamin D, calcium and iodine, which helps to regulate and maintain the health of the thyroid. <a href="http://www.sciencedaily.com/releases/2011/07/110720142346.htm" target="_hplink">According to an article last year in Science Daily</a>, researchers have targeted seaweed, which has been eaten for centuries in other parts of the world, as a possible rich source of bioactive peptides: <blockquote>Maria Hayes and colleagues Ciar?n Fitzgerald, Eimear Gallagher and Deniz Tasdemir note increased interest in using bioactive peptides, now obtained mainly from milk products, as ingredients in so-called functional foods. Those foods not only provide nutrition, but have a medicine-like effect in treating or preventing certain diseases. </blockquote> Seaweed is low-cal, too -- most brands have fewer than 50 calorie per package, according to Bauer. For more on the nutrition benefits of various types, <a href="http://www.oprah.com/food/Different-Types-of-Seaweed-Nutritional-Benefits-of-Seaweed" target="_hplink">click over to this list</a> from Oprah.com.

  • Shiitake Mushrooms

    ?"This delicacy has been shown to lower cholesterol and improve the immune response," says Fitzgerald. "Shiitake contains a compound lentinan, which has been found to have powerful anti-cancer properties." ? Lentinan is believed to <a href="http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/DietandNutrition/shiitake-mushroom" target="_hplink">stop or slow tumor growth</a>, according to the American Cancer Society. At least one clinical trial found lentinan, in conjunction with chemotherapy, helped stomach and colorectal cancer patients live longer. Animal studies, such as a study in mice that found lentinan in high purity <a href="http://www.ncbi.nlm.nih.gov/pubmed/12470439" target="_hplink">reduced the size of colon cancer tumors</a>, have shown even more promising results, according to the ACS.

  • Skim Milk

    While the taste can take some adjusting to if you're used to a richer milk, the fat-free variety is "low in calories while rich in several nutrients that are low in many Americans' diets," says Johnson, like calcium, vitamin D and potassium. ? And a recent study found that people who eat and drink low-fat dairy products, including skim milk, have a <a href="http://healthland.time.com/2012/04/20/skim-milk-drinkers-rejoice-you-may-have-a-lower-stroke-risk/" target="_hplink">lower stroke risk</a> than people who eat high-fat dairy foods.

  • Spinach

    This leafy green, along with kale (also on our list), is rich in antioxidants lutein and zeaxanthin, which keep eyesight sharp, says Joy Bauer. It's also <a href="http://www.ncbi.nlm.nih.gov/pubmed/16210712" target="_hplink">full of vitamin A</a> and packs a serious calcium punch, with <a href="http://ndb.nal.usda.gov/ndb/foods/show/3234?fg=&man=&lfacet=&count=&max=&qlookup=&offset=&sort=&format=Abridged&_action_show=Apply+Changes&Qv=1.8&Q5985=1.0" target="_hplink">245 milligrams in a cup</a> of the cooked stuff, <a href="http://www.huffingtonpost.com/2012/04/25/calcium-food-sources_n_1451010.html" target="_hplink">almost as much as a glass of milk</a>. A half-cup of cooked, fresh spinach also contains <a href="http://www.cdc.gov/nutrition/everyone/basics/vitamins/iron.html" target="_hplink">3.2 milligrams of iron</a> -- more than beef -- according to the CDC. (Keep in mind, however, that non-heme sources of iron don't absorb as easily, so eat your spinach with some vitamin-C-rich foods to make them more bioavailable.)

  • Strawberries

    These sweet red berries are low in calories and rich in fiber, says Johnson. Plus, they are packed with vitamin C: one serving (147 grams) contains <a href="http://ndb.nal.usda.gov/ndb/foods/show/2486" target="_hplink">over 86 milligrams</a>?-- <a href="http://www.huffingtonpost.com/2012/04/27/vitamin-c-foods_n_1457397.html#slide=911247" target="_hplink">more than an orange</a> and even more than one day's recommended amount, she says. Strawberries have also been linked to <a href="http://www.huffingtonpost.com/2012/04/26/cognitive-impairment-study-berries_n_1453557.html" target="_hplink">slower cognitive decline in older adults</a> and may protect the stomach in a way that could be used to <a href="http://www.sciencedaily.com/releases/2011/10/111025091541.htm" target="_hplink">treat stomach ulcers</a>.

  • Sunflower Sprouts

    "An ideal addition to salads to provide a different flavor, they have a great nutty taste that'll add some kick to your greens," says Heather Bauer. "They're loaded with health-boosting components such as chlorophyll, antioxidants and vitamin D for bone and muscle health. In addition, they contain tons of digestive enzymes, crucial for GI health." ? Sprouts in general may fight certain cancers, <a href="http://articles.timesofindia.indiatimes.com/2007-08-19/science/27973728_1_alfalfa-sprouts-hot-flashes-health-benefits" target="_hplink">help with menopause symptoms</a> and lower cholesterol, among other benefits, according to the <em>Times Of India</em>. However, they have taken some heat for possible involvement in <a href="http://www.huffingtonpost.com/craig-goldwyn/sprouts-e-coli-risk_b_875103.html" target="_hplink">recent outbreaks of food-borne illnesses</a>.

  • Sweet Potatoes

    ?"Sweet potatoes boast vitamin A and beta carotene, which makes them effective weapons to help keep your immune system strong," says Zied. They're also a good source of fiber, folate and potassium, adds Wixom. ? They can additionally give your skin a boost. Beta carotene <a href="http://www.self.com/fooddiet/blogs/healthybites/2009/09/recipe-roundup-the-sweet-potat.html" target="_hplink">jumpstarts skin cell production</a>, helping repair damage and leaving you looking silkier. ? But don't confuse them with yams. Turns out, the two aren't even related. In most cases, the orangey starch you're used to seeing labels "yams" is just <a href="http://www.huffingtonpost.com/2011/11/16/difference-between-sweet-potatoes-and-yams_n_1097840.html" target="_hplink">a sweet potato by the wrong name</a>.

  • Tomatoes

    Full of vitamin C and low in calories, tomatoes are also "rich in lycopene, which may help fight cancer," says Young. Lycopene, a <a href="http://www.huffingtonpost.com/2012/06/20/foods-for-longevity_n_1612828.html#slide=1146882" target="_hplink">fat-soluble nutrient</a>,?has been shown to help <a href="http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/DietandNutrition/lycopene" target="_hplink">fight prostate, lung and stomach cancers</a> in particular, according to the ACS.

  • Turmeric

    "Known for its significant anti-inflammatory properties, this root may provide <a href="http://cms.herbalgram.org/press/2010/TurmericBenefitsOsteoarthritis.html?t=1285777112" target="_hplink">relief for those with arthritis</a>," says Fitzgerald, as well as diabetes, allergies and Alzheimer's. "The <a href="http://www.ncbi.nlm.nih.gov/pubmed/16219905" target="_hplink">anti-cancer properties</a> of this popular Indian spice are impressive." ? Among those properties: University of Texas studies found that curcumin, the main component of turmeric, <a href="http://www.huffingtonpost.com/andrew-weil-md/turmeric-health-have-a-happy-new-year_b_798328.html" target="_hplink">stopped skin cancer growth</a> and slowed the spread of breast cancer to the lungs. It may also increase the effectiveness of chemotherapy and radiation. ? Plus, spices in general are smarter ways to add flavor to dishes than adding salt or fat.

  • Tuna?

    While you might think of sardines or salmon first when you consider healthy, fatty fish, tuna is not to be forgotten. It's a smart <a href="http://www.huffingtonpost.com/2012/03/05/iron-in-foods-the-best-di_n_1316332.html#s747030&title=Fish" target="_hplink">source of iron</a>, <a href="http://ndb.nal.usda.gov/ndb/foods/show/4563" target="_hplink">protein</a> and <a href="http://www.doh.wa.gov/CommunityandEnvironment/Food/Fish/HealthBenefits.aspx" target="_hplink">omega 3's</a>, which keep your brain functioning properly and reduce the risk of heart problems, among other benefits. ? Just be sure to look for <a href="http://www.huffingtonpost.com/eatingwell/healthy-fish_b_1387875.html" target="_hplink"><em>albacore</em> tuna that's been troll- or pole-caught</a> in the U.S. or British Columbia. EatingWell reported smaller, younger fish are usually caught this way, and typically have lower levels of mercury or other unwelcome contaminants. (Albacore is the light-colored tuna most often found in cans.)

  • Walnuts

    These nuts are "the one nut that is a good source of omega-3 oil," says Katz, notably <a href="http://www.huffingtonpost.com/2012/06/20/foods-for-longevity_n_1612828.html#slide=1146884" target="_hplink">alpha linolenic acid (ALA)</a>, which has been linked to decreasing inflammation. ?They also contain fiber and an array of vitamins, he adds, plus protein Young points out. ? "Walnuts made history in 2004 when they became the first food that the FDA allowed to make a qualified health claim," says Fitzgerald. "Supportive but not conclusive research shows that eating 1.5 ounces of walnuts per day, as part of a low-saturated-fat and low-cholesterol diet, and not resulting in increased caloric intake, <a href="http://www.walnuts.org/walnuts/index.cfm/health-professionals/walnuts-and-health/heart-health/" target="_hplink">may reduce the risk of coronary heart disease</a>."

  • Water

    Don't underestimate the power of a simple glass of water. Soaking up 91 ounces (women) or 125 ounces (men) a day <a href="http://www.huffingtonpost.com/2012/02/28/how-much-water-urine-color-chart_n_1305129.html" target="_hplink">keeps skin smooth</a> and memory sharp, <a href="http://www.everydayhealth.com/water-health/water-body-health.aspx" target="_hplink">protects the joints</a> and can even help you <a href="http://www.cnn.com/2010/HEALTH/08/23/drink.water.lose.weight/index.html" target="_hplink">shed those couple extra pounds</a>. ? Not to mention, the body couldn't perform a number of key processes without H20. "Water helps the body digest food, absorb nutrients from food and then get rid of the unused waste," according to experts from the Penn Instutute on Aging. They also point out you don't only have to drink it -- there is plenty of water in high-water-content foods like <a href="http://www.huffingtonpost.com/2012/02/24/6-hydrating-foods_n_1297196.html" target="_hplink">watermelon and cucumbers</a> and in other liquids, too. ? And did we mention it's the only food or drink with absolutely zero calories.

  • White Tea

    "Black, green and white teas contain antioxidants?called flavonoids that studies suggest may have strong anti-inflammatory and immune boosting properties, be protective against certain cancers, cardiovascular disease and diabetes," says Heller. "Just don't load your tea up with sugar and cream!" ? White tea in particular may have a <a href="http://www.webmd.com/diet/features/tea-types-and-their-health-benefits" target="_hplink">more powerful anticancer punch</a>, according to WebMD. That may be at least in part due to its higher concentration of antioxidants compared to green tea, Katz explains. "Green tea is made from the mature leaves; white tea from the buds before the leaves unfold," he says. ? White tea's anti-inflammatory properties may also help <a href="http://www.webmd.com/diet/features/tea-types-and-their-health-benefits" target="_hplink">reduce wrinkles and fight rheumatoid arthritis</a>, according to a 2009 study.

  • Source: http://www.huffingtonpost.com/2012/06/29/healthy-food-healthiest-list_n_1636409.html

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    Doing Home Improvement Projects ? Essential Strategies Revealed ...

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    Planning home improvement projects can be difficult. Using the information in this article, it should help you make these decisions much more easily. There are many factors that help determine how things turn out, such as your budget, the quality of any help you hire, and whether the changes you make actually increase your home?s appeal and value. Home improvement projects can be difficult, and making the right decisions early on is important in regard to the success of what you aspire to do.|

    Planning is absolutely essential, especially when it comes to home improvement projects that need to be done right. Getting the job done is something that will be much easier, especially if you take the time to write out exactly what you want to do for your home improvement project. Your home improvement project endeavor will definitely succeed if you utilize some of the aforementioned tips.|By carefully planning your home improvement efforts, you can save time and money and ensure the best results. A professional opinion is sometimes an easy way to saving a lot of money on your next home improvement project or renovation. You should never guess on what you need to do. Always find out the facts! No surprises! That is the benefit that you will receive from doing your proper planning prior to the renovations and avoiding unpleasant surprises that may manifest.

    You have read through this article and have a better appreciation about home improvements, hopefully. However the situation does not always remain predictable, and it is usually not so easy to see where things are going. Once that occurs, of course there will be issues that appear that you were not expecting. You have read the three points we have discussed, and it of course is prudent that you investigate further. We know you can get that job accomplished since it is information and there is plenty of it around. However, you need to do responsible research on anything. After all this much time has passed, we all know what things are like on the web.|If you have done even a little reading on home improvements thus far, you know it involves so many people, everywhere. It is completely normal for all of us to just go along with life until problems begin to arise, and then we take notice.

    So what we recommend is that you start paying closer attention and be mindful about it. The interesting thing about us humans is we usually do not pay a lot of attention to prevention. Have you not ever noticed that about people or even your self? It does seem to be very prevalent in our opinion. If you can put things in place that will help you, then that is smart; and we mean becoming more aware about it.|If you take a look at what is here, you will see that these are rock solid pieces of advice on the subject matter.

    All you need to do is take a close look at this, and you will be able to tell that it is right on and especially with the supporting research. This is definitely not where your progress ends, though, and therefore continue your quest to know more about home improvements. The one particular thing to avoid, always, is achieving insufficient knowledge prior to action.

    But one thing that we always do is try to let people know there is a lot more that needs to be discovered. Remember as you go on with this that it is perfectly reasonable to decide on something that is most pertinent for further exploration.|We are willing to bet that were not aware of the points covered about home improvements in this article ? that is a common response we get from people who contact us. So if it suits your fancy, or need, then you are at your leisure to delve into it and know all about it.

    Bring an open mind to the table as you do this, though, and many important tips will jump out at you. But do not feel shy about exploring anything that you feel may shed more light on this. Then, since you know it is important, simply drill down to discover more about it.

    You can work with that until you are satisfied and then expand or do the same with another point from this article.|Discovering more about home improvements is much like anything else in that you will have to resolve things along the way.

    Everybody likes to talk about info overload, and that is really a serious issue in this regard. What we all see very clearly are competing points of view, opinions and even conflicting research results. When you read about particular strategies for your online business, keep those points in mind as we are certain you will encounter this phenomena. There is really not much else you can do about that, but you can sharpen your mind so you will be protected.

    There will be unique issues when researching any subject and that is no less true with home improvement project. That is normal and is a near-universal experience; we encountered the same things. So merely work with it the best you can and take things as they come; you will be fine. Detailed descriptions with examples are available when you visit moth balls blog. It will be valuable to read-up about moth killer article, as well, because that is a great augment to the rest of the information. That is something that will give you a wide angle view ? just like the lens.

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    Source: http://corvikaye8.typepad.com/blog/2012/06/doing-home-improvement-projects-essential-strategies-revealed.html

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    Friday, June 29, 2012

    Preventing the immune system from going haywire during sepsis

    Preventing the immune system from going haywire during sepsis [ Back to EurekAlert! ] Public release date: 29-Jun-2012
    [ | E-mail | Share Share ]

    Contact: Felpe del Pizzol
    piz@unesc.net
    44-777-811-8025
    Publicase Comunicao Cientfica

    The immune system during sepsis

    Septic shock is the most severe outcome associated with pathogen infection in the bloodstream. It is a life-threatening condition invariably leading to multiple organ dysfunctions. Currently, septic shock is one of the most frequent causes of death in intensive care units worldwide.

    However, it is already known that sepsis-induced multiple organ dysfunction is not a direct effect of the pathogen invasion itself but rather an overreaction of the host immune system against the infection. Many strategies aiming at holding back the extreme response of the immune system have been developed but little progress has been made.

    A group of researchers from Santa Catarina, Rio Grande do Sul and So Paulo, in Brazil, have shown that blocking the receptor of bombesin/gastrin-releasing peptide (GRP), a peptide involved with the activation of neutrophil and macrophage immune cells, improves survival in sepsis animal models. Working with RC-3095, an antagonist of the GRP receptor developed by Nobel Laureate Dr Andrew Schally, the group showed that this molecule attenuates the release of the host's exacerbating immune response elements, and reveals a new inflammatory pathway and potential target for new drugs. The study was part of a research effort to investigate additional functions and potential clinical applications for the GRP receptor, initiated by Drs Gilberto Schwartsmann and Rafael Roesler at the Federal University of Rio Grande do Sul.

    Led by Drs Felipe Dal-Pizzol and Fabricia Petronilho at the Universidade do Extremo Sul Catarinense, in Brazil, the group has recently teamed up with Drs Andrew Schally and Norman L. Block at the University of Miami Miller School of Medicine to investigate the potential link between GRP and TLR-4, a receptor found in neutrophils and macrophages. TLR-4 is one of the molecules responsible for spreading the word that the body has been invaded by microbes and that something must be done quickly.

    In a paper entitled "Gastrin-releasing peptide receptor antagonism induces protection from lethal sepsis: involvement of toll-like receptor 4 signaling" and published in Molecular Medicine, the group shows that RC-3095 reduces the levels of circulating TLR-4 and other immune elements associated with an extreme inflammatory response. Additionally, the group has found that patients with septic shock have greater amounts of GRP if compared to those with less severe forms of sepsis. These higher levels of GRP may explain why septic shock patients develop multiple organ dysfunctions and present the highest mortality rate among sepsis patients.

    The study also shows that in animal models, administration of RC-3095 limits the spread of infection beyond the abdominal cavity, indicating the potential of RC-3095 in preventing the complete breakdown of the host's system.

    Besides its clinical relevance, the study provides new insights on the roles of key players involved in the complex communication network triggering extreme inflammatory responses. Together, these findings may open new avenues for the development of effective therapeutic strategies to treat sepsis and related inflammatory diseases.

    ###

    The research was funded by the National Institute for Translational Medicine (INCT-TM) and the National Council for Scientific and Technological Development (CNPq) in Brazil.

    A pdf of the article can be found at http://www.molmed.org/pdfstore/12_083_Petronilho.pdf


    [ Back to EurekAlert! ] [ | E-mail | Share Share ]

    ?


    AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


    Preventing the immune system from going haywire during sepsis [ Back to EurekAlert! ] Public release date: 29-Jun-2012
    [ | E-mail | Share Share ]

    Contact: Felpe del Pizzol
    piz@unesc.net
    44-777-811-8025
    Publicase Comunicao Cientfica

    The immune system during sepsis

    Septic shock is the most severe outcome associated with pathogen infection in the bloodstream. It is a life-threatening condition invariably leading to multiple organ dysfunctions. Currently, septic shock is one of the most frequent causes of death in intensive care units worldwide.

    However, it is already known that sepsis-induced multiple organ dysfunction is not a direct effect of the pathogen invasion itself but rather an overreaction of the host immune system against the infection. Many strategies aiming at holding back the extreme response of the immune system have been developed but little progress has been made.

    A group of researchers from Santa Catarina, Rio Grande do Sul and So Paulo, in Brazil, have shown that blocking the receptor of bombesin/gastrin-releasing peptide (GRP), a peptide involved with the activation of neutrophil and macrophage immune cells, improves survival in sepsis animal models. Working with RC-3095, an antagonist of the GRP receptor developed by Nobel Laureate Dr Andrew Schally, the group showed that this molecule attenuates the release of the host's exacerbating immune response elements, and reveals a new inflammatory pathway and potential target for new drugs. The study was part of a research effort to investigate additional functions and potential clinical applications for the GRP receptor, initiated by Drs Gilberto Schwartsmann and Rafael Roesler at the Federal University of Rio Grande do Sul.

    Led by Drs Felipe Dal-Pizzol and Fabricia Petronilho at the Universidade do Extremo Sul Catarinense, in Brazil, the group has recently teamed up with Drs Andrew Schally and Norman L. Block at the University of Miami Miller School of Medicine to investigate the potential link between GRP and TLR-4, a receptor found in neutrophils and macrophages. TLR-4 is one of the molecules responsible for spreading the word that the body has been invaded by microbes and that something must be done quickly.

    In a paper entitled "Gastrin-releasing peptide receptor antagonism induces protection from lethal sepsis: involvement of toll-like receptor 4 signaling" and published in Molecular Medicine, the group shows that RC-3095 reduces the levels of circulating TLR-4 and other immune elements associated with an extreme inflammatory response. Additionally, the group has found that patients with septic shock have greater amounts of GRP if compared to those with less severe forms of sepsis. These higher levels of GRP may explain why septic shock patients develop multiple organ dysfunctions and present the highest mortality rate among sepsis patients.

    The study also shows that in animal models, administration of RC-3095 limits the spread of infection beyond the abdominal cavity, indicating the potential of RC-3095 in preventing the complete breakdown of the host's system.

    Besides its clinical relevance, the study provides new insights on the roles of key players involved in the complex communication network triggering extreme inflammatory responses. Together, these findings may open new avenues for the development of effective therapeutic strategies to treat sepsis and related inflammatory diseases.

    ###

    The research was funded by the National Institute for Translational Medicine (INCT-TM) and the National Council for Scientific and Technological Development (CNPq) in Brazil.

    A pdf of the article can be found at http://www.molmed.org/pdfstore/12_083_Petronilho.pdf


    [ Back to EurekAlert! ] [ | E-mail | Share Share ]

    ?


    AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


    Source: http://www.eurekalert.org/pub_releases/2012-06/pcc-pti062912.php

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    Debt crisis: live

    14.11 An interesting question on an in-out referendum on the EU, which was side-stepped without a definite answer...

    14.08 More from David Cameron, who is now taking questions:

    QuoteEurope is changing, there's a change taking place as the countries of the eurozone follow the remorseless logic of having a single currency. My job is to make sure we ensure all the safeguards we need... so that our say in the single market is safeguarded.

    Britain is not going to cede more powers to Brussels... I think there are powers that should be going in the other direction.

    I completely understand why some people want an in-out referendum. some people just want to get out: 'stop the bus, I want to get out'.

    We used to be part of those bailout schemes, and I got us out of those bailout schemes, and that's saved us real money.

    14.00 On banking union, Cameron says he expects to see "enhanced cooperation" under existing treaties, so that will offer "lots of protection" for the single market. But a single European regulator is not something which the UK should be accountable to - that should only apply to the eurozone, not the EU, he says:

    QuoteIn my view that must be the Bank of England for our banks... rather than a single European regulator. It's never entirely clear how far these changes will go, exactly which treaty clauses will be used... that's one of the reasons that when you come to these summits you've got to be absolutely focussed on the text and what you're signing up to. We want a functional eurozone, not a dysfunctional eurozone, but we need those safeguards. Permanent vigilance is required.

    13.54 A quick aside to the Libor scandal - David Cameron says that he'll ensure that FSA fines are used to benefit the taxpayer and not reduce future FSA payments by the banks.

    13.53 He's said that he is against a larger EU budget:

    QuoteWhat we need to do is not spend more, but spend better. I made it absolutely clear that the British rebate is not up for discussion.

    13.50 David Cameron is now speaking in Brussels:

    QuoteWe have to stand behind our own banks, but I don't want British taxpayers paying for European banks.

    13.24 Francois Hollande says that a financial transaction tax will be in place before the end of 2012, just in time for Christmas. He says that Germany strongly backs the plan, but that a rate hasn't yet been agreed on.

    But what won't be ready by the end of the year is France's ratification of the fiscal pact, he adds...

    12.54 There's another podium in Brussels, next to Merkel's, this one standing in front of a Union Flag, so we can expect a David Cameron announcement soon.

    12.48 Merkel says that many countries had asked for the ESM's preferred creditor status to be kept intact, apart from in the case of Spain. She also says that conditions will still apply to any bailouts.

    12.39 Merkel says that the EFSF will be used to recapitalise Spanish banks, then the ESM will take over later - without its preferred status (that is, being first in line to reclaim money in case of default). This is important, because it will reassure private investors that they won't be as likely to lose out. But this will only apply to Spain, warns Merkel, not other countries that seek help in the same way.

    12.34 Angela Merkel is now giving a press conference:

    QuoteWe've had a debate that was partially controversial... but this doesn't come as a surprise.

    12.21 A quick update on European markets, which are firmly holding on to the gains they made in early trading.

    The FTSE 100 has edged up 1.38pc - and is now down just 0.05pc on the year - the CAC is up 2.79pc and the DAX has risen 2.57pc.

    11.58 German lawmakers are - right now - holding a special meeting to discuss what the opposition Social Democrat party sees as a government U-turn on eurozone bailouts.

    Just hours before a crunch vote by both houses of parliament on the EU fiscal pact and the permanent ESM bailout fund, the centre-left SPD party called for an extraordinary meeting of the parliamentary finance committee.

    11.27 Simon Denham, chief executive of Capital Spreads, points out that Spain's 10-year bond yield is now floating around 6.55pc - not as low as could have been hoped for after an unexpected result from the EU summit - and no more sustainable in reality than 8pc:

    QuoteThe euphoria over the euro banking agreement has sent stocks higher but the shine seems to be fading as I write.

    In reality the banking side was always the easier bit to the problem in that the banks are actual legal entities who have to operate in a fiscally responsible manner (don?t laugh) whereas national governments clearly do not.

    The real question is still out there, namely the pooling of eurobond risk which the Germans are naturally averse to.

    11.14 Eurozone consumer inflation held steady at 2.4pc year-on-year in June, keeping the door open for the ECB to cut interest rates. Christoph Weil, of Commerzbank, said:

    QuoteWe assume that the inflation rate will not continue its downward trend in the coming months. This is based on our forecast for the oil price. We think the recent fall of the oil price was exaggerated and expect the price for a barrel of Brent to exceed $100 again in the second half of the year.

    Nevertheless, the ECB may react with relief to the recent decline of the inflation rate as it reduces the risk that the collective bargaining parties will assume higher inflation rates in their pay negotiations. Furthermore, inflation risks are currently low. In view of weak demand, companies are finding it difficult to raise prices.

    There is thus no obstacle to an ECB rate cut from the side of inflation. We expect the central bank to lower its repo rate from 1pc to 0.75pc at its meeting next week.

    10.56 More from Mervyn King: the UK economy is at risk of a "vicious circle" of reduced bank lending if banks' assets deteriorate. Uncertainty and tighter credit conditions have acted as "strong headwinds" to UK recovery.

    10.53 Mervyn King, governor of the Bank of England, says that the problems in the eurozone are deep-seated and not something that UK authorities can fix. He adds that a Greek exit would "probably be manageable" for British banks.

    10.52 We have a video for you from this morning's press conference with Herman Van Rompuy and Jos? Manuel Barroso.

    10.46 So David Cameron is calling it a victory and claiming that he helped shoot down proposals that might have subjected the City to regulation under plans for a eurozone ?banking union?. But Bruno Waterfield says there's a bit more to it than that...

    10.25 Our man in Brussels, Bruno Waterfield, brings us this update from the EU summit, which suggest that the discussion got rather heated last night:

    David Cameron is declaring victory over Brussels proposals that all banks, in every one of the EU?s 27 countries, should be placed under the direct control of a powerful European ?banking supervision system?.

    The Prime Minister, warning that he could block the use of the ECB as a eurozone bank regulator, had text deleted from the EU summit agreement after bad-tempered exchanges last night.

    The summit text had said: ?Existing legislative props on bank resolution and deposit guarantees should be adopted by the end of year. Building on theses the commission will submit by the end of 2012 further legislative propsoals in a single European banking supervision system covering all banks, a European deposit guarantee scheme and a European bank resolution scheme.?

    In a major blow for Michel Barnier, the French commissioner responsible for EU financial regulation, the move to a pan-EU system are scrapped after a row predicted by the Daily Telegraph yesterday.

    Summit language encouraging eurozone members to ?deepen coordination of their economic policies? was also dropped.

    10.19 Retail sales data out from Greece this morning shows a 13.5pc drop in April, month-on-month. That's an improvement on the previous month, which saw a fall of 16.2pc, but hardly worthy of celebration. In just two months that comes to almost an erosion of almost a third of retail sales...

    10.02 While we're on the subject of the ECB, eurozone bank loans to the private sector contracted last month. The central bank's regular monthly money supply data showed that loans contracted 0.1pc in May after growing by 0.2pc in April.

    09.53 The Greek bank jog (not quite a run) continues, with worried businesses and customers pulling their money out to invest somewhere they see as safer.

    ECB data out this morning show that private-sector deposits in Greek banks fell almost 5pc in May after slight increases in the two previous months. The total fell to ?163bn from ?171.5bn. They are at their lowest level in six years.

    09.24 David Cameron has spoken to the BBC on his way back in to the summit in Brussels this morning, saying that "important steps forward" were taken last night. He says more was needed for short term stability.

    EU leaders will have filled up on strong coffee over breakfast - talks ended at 4.30 this morning after dragging on for more than 13 hours.

    09.18 Some contradictory statements are emerging this morning. Angela Merkel says there will still be conditions to meet for countries which need bank recapitalisation, and that to be involved in the bond-buying programme there will still be troika checks. But Italy's PM Mario Monti says those who seek EFSF or ESM aid won't need to have troika oversight. He's also added that Italy doesn't intend to seek such help "at this time".

    09.11 Fabrizio Gora tweets a picture of Libero's front page this morning, which is unlikely to please the German chancellor.

    08.55 They say bad news comes in threes, and that'll ring true for Angela Merkel this morning. First Germany was knocked out of Euro 2012, then she was forced to back down at the EU summit and now German retail sales have dropped for a second month running in May. Sales unexpectedly fell 0.3pc from April.

    08.34 Kathleen Brooks, research director at Forex.com, brings us her views on the EU summit deal:

    QuoteEurozone authorities have attempted to break the toxic link between banks and sovereigns. The move on Spain is extremely positive in our view. Although it doesn?t irradiate the problem of bad loans on Spain?s banks? balance sheets it does mean that banking debt won?t clog up Spain?s sovereign balance sheet that was relatively healthy before the banks started to fail. This should reduce Spain?s borrowing costs in the short to medium term.

    The move on scrapping credit seniority for bailout loans to Spain?s banks is a very positive move to us as it encourages the private sector to invest in Spain and Italy?s sovereign debt.

    But there are also problems, she warns:

    QuoteThe EFSF/ESM rescue funds only have ?500bn of available capital, yet the total liabilities on Spain?s and Italy?s balance sheets? top ?2.4 trillion... This could curb the market?s enthusiasm as we haven?t heard any signs that these bailout funds will be topped up.

    08.18 European markets have surged in early trade after the news from the EU summit just a few hours ago. Futures were pointing to climbs across the board, apart from in Germany and France - but in the event even they've decided to join the rally.

    The FTSE 100 has climbed 1.74pc, the DAX is up 2.39pc and the CAC has gained 2.86pc. Spain's IBEX is 4.05pc higher and Italy's FTSE MIB is up 3.07pc.

    08.01 The fake Angela Merkel has a knack for summing up the situation with a single tweet, and doesn't disappoint this morning.

    07.30 European Council chairman Herman Van Rompuy seems relieved that a deal has been done. There were some worrying moments during last night's stand-off between Spain and Italy and Germany.

    He said the aim was to create a supervisory mechanism for eurozone banks involving the European Central Bank to break the "vicious circle" of dependence between banks and sovereign governments.

    QuoteWe are opening the possibility to countries that are well behaving to make use of financial stability instruments in order to reassure markets and to get again some stability around some of the sovereign bonds of our member states. The aim is of course to make the euro an irreversible project.

    07.15 Just as well for France that EU leaders have agreed a ?120bn growth pact, as the figures out today show first quarter growth stalled.

    National statistics agency INSEE says its final estimate of GDP was unchanged quarter-on-quarter, confirming an initial estimate published last month. The eurozone's second largest economy grew just 0.1pc in the fourth quarter.

    07.05 Yields on 10-year Spanish and Italian bonds fell to 6.48pc and 5.87pc respectively in early trading, after eurozone leaders agreed a plan to allow rescue funds to be used to stabilise debt markets and directly recapitalise banks. One trader said:

    QuoteIt's definitely risk on for now, but it looks like Germany have been rather backed into a corner and we'll have to see what comes out today.

    German 10-year bond yields rose 10 basis points to 1.61pc.

    06.45 Mario Monti, the Italian Prime Minister, celebrated the agreement as a ?very important deal for the future of the EU and the eurozone?. Bruno Waterfield writes:

    QuoteHe could not resist reminding Angela Merkel, the German Chancellor, that Italy had also won on the football pitch, by defeating Germany two goals to one for a place in the finals of the European Championship.

    Here is a summary of what they agreed:

    ? Spanish banks will be recapitalised directly by allowing a ?100bn EU bailout to be transferred off Spain?s balance sheet after the European Central Bank takes over as the single currency?s banking supervisor at the end of the year.

    ? Relief for Spain was accompanied by a pledge to begin purchases of Italian bonds using EU bailout funds to reduce Italy?s borrowing costs with a lighter set of conditions, based on meeting Brussels fiscal targets rather than intrusive IMF oversight.

    ? A promise was also made to ?examine the situation of the Irish financial sector? offering possible relief to Ireland by relieving the government balance sheet debt burden.

    ? The Spanish bank bailout, to be agreed on 9 July, will initially use the euro?s European Financial Stability Facility (EFSF) before it is transferred into a new permanent fund later this year.

    06.40 Despite apparent market optimism, some scepticism remains. Jackson Wong, vice president at Tanrich Securities in Hong Kong. said:

    QuoteWe don't expect a magical formula that can solve the problem right out from the EU summit. However, if we can see the stances from all the leaders, especially from Germany - that they are heading in the right direction - I think going forward, it should be OK.


    Euro rise in Asian trading on news of the eurozone agreement. Graph: Bloomberg

    06.38 The euro spiked against the dollar after news of the deal, and Asian stock markets rose sharply. Japan's Nikkei rose 1.4pc and Hong Kong's Hang Seng gained 2.2pc.

    However, while the shares in London, Italy and Spain are expected to rise when market open on Friday, those in Germany and France look set to fall.

    06.35 So, Monti and Rajoy got their way, with German Chancellor Angela Merkel retreating. Bruno Waterfield in Brussels sums it up succinctly, but with a warning:

    Ambushed - she always gets her revenge in the end, as Sarko discovered.

    06.34 It looks like those late night summits are back. Eurozone leaders agreed early this morning to take emergency action to bring down Italy's and Spain's spiralling borrowing costs and to create a single supervisory body for eurozone banks by the end of this year, a first step towards a European banking union.

    It followed a tense first day at the EU summit, with Italian prime minister Mario Monti and his Spanish counterpart, Mariano Rajoy, refusing to sign off on a ?120bn growth package until EU paymaster Germany approved short-term measures to ease their cost of credit.

    06.30 Good morning and welcome back to our live coverage of the European debt crisis.

    Debt crisis live: archive

    Source: http://telegraph.feedsportal.com/c/32726/f/568312/s/20d5b24f/l/0L0Stelegraph0O0Cfinance0Cdebt0Ecrisis0Elive0C93638680CDebt0Ecrisis0Elive0Bhtml/story01.htm

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